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We analyze theoretically the effects of excluded-volume interactions betweenmotors on the dynamics of a cargo driven by multiple motors. The modelconsidered shares many commons with other recently proposed in the literature,with the addition of direct interaction between motors and motor back steps.The cargo is assumed to follow a continuum Langevin dynamics, while individualmotors evolve following a Monte Carlo algorithm based on experimentallyaccessible probabilities for discrete forward and backward jumps, andattachment and detachment rates. The links between cargo and motors areconsidered as non linear springs. By means of numerical simulations we computethe relevant quantities characterizing the dynamical properties of the system,and we compare the results to those for non interacting motors. We find thatinteractions lead to quite relevant changes in the force-velocity relation forcargo, with a considerable reduction of the stall force, and cause also anotable decrease of the run length. These effects are mainly due totraffic-like phenomena in the microtubule. The consideration of severalparallel tracks for motors reduces such effects. However, we find that forrealistic values of the number of motors and the number of tracks, theinfluence of interactions on the global parameters of transport of cargo arefar from being negligible. Our studies provide also an analysis of therelevance of motor back steps on the modeling, and of the influence ofdifferent assumptions for the detachment rates. In particular, we discuss thesetwo aspects in connection with the possibility of observing processive backmotion of cargo at large load forces.

Influence of direct motor-motor interaction in models for cargo transport by a single team of motors