English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Cancer cells are known to modify their micro-environment such that it cansustain a larger population, or, in ecological terms, they construct a nichewhich increases the carrying capacity of the population. It has however beenargued that niche construction, which benefits all cells in the tumour, wouldbe selected against since cheaters could reap the benefits without paying thecost. We have investigated the impact of niche specificity on tumour evolutionusing an individual based model of breast tumour growth, in which the carryingcapacity of each cell consists of two components: an intrinsic,subclone-specific part and a contribution from all neighbouring cells. Analysisof the model shows that the ability of a mutant to invade a resident populationdepends strongly on the specificity. When specificity is low selection ismostly on growth rate, while high specificity shifts selection towardsincreased carrying capacity. Further, we show that the long-term evolution ofthe system can be predicted using adaptive dynamics. By comparing the resultsfrom a spatially structured vs.\ well-mixed population we show that spatialstructure restores selection for carrying capacity even at zero specificity,which a poses solution to the niche construction dilemma. Lastly, we show thatan expanding population exhibits spatially variable selection pressure, wherecells at the leading edge exhibit higher growth rate and lower carryingcapacity than those at the centre of the tumour.

The evolution of carrying capacity in constrained and expanding tumour cell populations