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We define a measure of coherent activity for gene regulatory networks, aproperty that reflects the unity of purpose between the regulatory agents witha common target. We propose that such harmonious regulatory action is desirableunder a demand for energy efficiency and may be selected for under evolutionarypressures. We consider two recent models of the cell-cycle regulatory networkof the budding yeast, Saccharomyces cerevisiae, as a case study and calculatetheir degree of coherence. A comparison with random networks of similar sizeand composition reveals that the yeast's cell-cycle regulation is wired toyield and exceptionally high level of coherent regulatory activity. We alsoinvestigate the mean degree of coherence as a function of the network size,connectivity and the fraction of repressory/activatory interactions.

Coherent regulation in yeast cell cycle network