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The extra-cellular microenvironment has a fundamental role in tumor growthand progression, strongly affecting the migration strategies adopted by singlecancer cells during metastatic invasion. In this study, we use a novelmicrofluidic device to investigate the ability of mesenchymal and epithelialbreast tumor cells to fluidize and migrate through narrowing microstructuresupon chemoattractant stimulation. We compare the migration behavior of twomesenchymal breast cancer cell lines and one epithelial cell line, and findthat the epithelial cells are able to migrate through the narrowestmicroconstrictions as the more invasive mesenchymal cells. In addition, wedemonstrate that migration of epithelial cells through a highly compressiveenvironment can occur in absence of a chemoattractive stimulus, thus evidencingthat they are just as prone to react to mechanical cues as invasive cells.

Normal epithelial and triple-negative breast cancer cells show the same invasion potential in rigid spatial confinement