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Some recent results for a three--dimensional, semi--classical, tight--bindingmodel for DNA show that there are two types of polarons, named radial and twistpolarons, that can transport charge along the DNA molecule. However, theexistence of two types of base pairs in real DNA, makes it crucial to find outif charge transport also exist in DNA chains with different base pairs. In thispaper we address this problem in its simple case, an homogeneous chain exceptfor a single different base pair, what we call a base-pair inhomogeneity, andits effect on charge transport. Radial polarons experience either reflection ortrapping. However, twist polarons are good candidates for charge transportalong real DNA. This transport is also very robust with respect to weakparametric and diagonal disorder.Comment: 21 pages, 10 figure

Effect of base-pair inhomogeneities on charge transport along the DNA molecule, mediated by twist and radial polarons