English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

In order to fully exploit the ballistic potential of particle therapy, wepropose an online range monitoring concept based on high-resolutionTime-Of-Flight (TOF)-resolved Prompt Gamma (PG) detection in a single protoncounting regime. In a proof of principle experiment, different types ofmonolithic scintillating gamma detectors are read in time coincidence with adiamond-based beam hodoscope, in order to build TOF spectra of PG generated ina heterogeneous target presenting an air cavity of variable thickness. Sincethe measurement was carried out at low beam currents ($<$ 1 proton/bunch) itwas possible to reach excellent coincidence time resolutions, of the order of100 ps ($\sigma$). Our goal is to detect possible deviations of the protonrange with respect to treatment planning within a few intense irradiation spotsat the beginning of the session and then carry on the treatment at standardbeam currents. The measurements were limited to 10 mm proton range shift. AMonte Carlo simulation study reproducing the experiment has shown that a 3 mmshift can be detected at 2$\sigma$ by a single detector of $\sim 1.4 \times10^{-3}$ absolute detection efficiency within a single irradiation spot($\sim$10$^{8}$ protons) and an optimised experimental set-up.

Ultra-fast prompt gamma detection in single proton counting regime for range monitoring in particle therapy