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We study gauge threshold corrections for systems of fractional branes atlocal orientifold singularities and compare with the general Kaplunovsky-Louisexpression for locally supersymmetric N=1 gauge theories. We focus on branes atorientifolds of the C^3/Z_4, C^3/Z_6 and C^3/Z_6' singularities. We provide aCFT construction of these theories and compute the threshold corrections. Gaugecoupling running undergoes two phases: one phase running from the bulk windingscale to the string scale, and a second phase running from the string scale tothe infrared. The first phase is associated to the contribution of N=2 sectorsto the IR beta functions and the second phase to the contribution of both N=1and N=2 sectors. In contrast, naive application of the Kaplunovsky-Louisformula gives single running from the bulk winding mode scale. The discrepancyis resolved through 1-loop non-universality of the holomorphic gauge couplingsat the singularity, induced by a 1-loop redefinition of the twisted blow-upmoduli which couple differently to different gauge nodes. We also study thephysics of anomalous and non-anomalous U(1)s and give a CFT description of howmasses for non-anomalous U(1)s depend on the global properties of cycles.

Gauge Threshold Corrections for Local Orientifolds