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Ion-mobility spectrometry (IMS) is an analytical technique used to separateand identify ionized gas molecules based on their mobility in a carrier buffergas. Such methods come in a large variety of versions that currently allow ionidentification at and above the millimeter scale. Here, we present a design fora cross-flow-IMS method able to generate and detect ions at the sub-millimeterscale. We propose a novel ion focusing strategy and tested it in a prototypedevice using Nitrogen as a sample gas, and also with simulations using fourdifferent sample gases. By introducing an original lobular ion generationlocalized to a few ten of microns and substantially simplifying the design, ourdevice is able to keep constant laminar flow conditions for high flow rates. Inthis way, it avoids the turbulences in the gas flow, which would occur in otherion-focusing cross-flow methods limiting their performance at thesub-millimeter scale. Scalability of the proposed design can contribute toimprove resolving power and resolution of currently available cross-flowmethods.

Scalable design of an IMS cross-flow micro-generator/ion detector