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Nanopore based sequencing has demonstrated significant potential for thedevelopment of fast, accurate, and cost-efficient fingerprinting techniques fornext generation molecular detection and sequencing. We propose a specificmulti-layered graphene-based nanopore device architecture for the recognitionof single DNA bases. Molecular detection and analysis can be accomplishedthrough the detection of transverse currents as the molecule or DNA basetranslocates through the nanopore. To increase the overall signal-to-noiseratio and the accuracy, we implement a new "multi-point cross-correlation"technique for identification of DNA bases or other molecules on the molecularlevel. We demonstrate that the cross-correlations between each nanopore willgreatly enhance the transverse current signal for each molecule. We implementfirst-principles transport calculations for DNA bases surveyed across amulti-layered graphene nanopore system to illustrate the advantages of proposedgeometry. A time-series analysis of the cross-correlation functions illustratesthe potential of this method for enhancing the signal-to-noise ratio. This workconstitutes a significant step forward in facilitating fingerprinting of singlebiomolecules using solid state technology.

Correlation Dynamics and Enhanced Signals for Serial DNA Sequencing