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We present a catalog of galaxy clusters selected via their Sunyaev-Zel'dovich(SZ) effect signature from 2500 deg$^2$ of South Pole Telescope (SPT) data.This work represents the complete sample of clusters detected at highsignificance in the 2500-square-degree SPT-SZ survey, which was completed in2011. A total of 677 (409) cluster candidates are identified above asignal-to-noise threshold of $\xi$ =4.5 (5.0). Ground- and space-based opticaland near-infrared (NIR) imaging confirms overdensities of similarly coloredgalaxies in the direction of 516 (or 76%) of the $\xi$>4.5 candidates and 387(or 95%) of the $\xi$>5 candidates; the measured purity is consistent withexpectations from simulations. Of these confirmed clusters, 415 were firstidentified in SPT data, including 251 new discoveries reported in this work. Weestimate photometric redshifts for all candidates with identified opticaland/or NIR counterparts; we additionally report redshifts derived fromspectroscopic observations for 141 of these systems. The mass threshold of thecatalog is roughly independent of redshift above $z$~0.25 leading to a sampleof massive clusters that extends to high redshift. The median mass of thesample is $M_{\scriptsize 500c}(\rho_\mathrm{crit})$ ~ 3.5 x 10$^{14} M_\odoth^{-1}$, the median redshift is $z_{med}$ =0.55, and the highest-redshiftsystems are at $z$>1.4. The combination of large redshift extent, cleanselection, and high typical mass makes this cluster sample of particularinterest for cosmological analyses and studies of cluster formation andevolution.

Galaxy Clusters Discovered via the Sunyaev-Zel'dovich Effect in the 2500-square-degree SPT-SZ survey