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New transiting planet candidates are identified in sixteen months (May 2009 -September 2010) of data from the Kepler spacecraft. Nearly five thousandperiodic transit-like signals are vetted against astrophysical and instrumentalfalse positives yielding 1,091 viable new planet candidates, bringing the totalcount up to over 2,300. Improved vetting metrics are employed, contributing tohigher catalog reliability. Most notable is the noise-weighted robust averagingof multi-quarter photo-center offsets derived from difference image analysiswhich identifies likely background eclipsing binaries. Twenty-two months ofphotometry are used for the purpose of characterizing each of the newcandidates. Ephemerides (transit epoch, T_0, and orbital period, P) aretabulated as well as the products of light curve modeling: reduced radius(Rp/R*), reduced semi-major axis (d/R*), and impact parameter (b). The largestfractional increases are seen for the smallest planet candidates (197% forcandidates smaller than 2Re compared to 52% for candidates larger than 2Re) andthose at longer orbital periods (123% for candidates outside of 50-day orbitsversus 85% for candidates inside of 50-day orbits). The gains are larger thanexpected from increasing the observing window from thirteen months (Quarter 1--Quarter 5) to sixteen months (Quarter 1 -- Quarter 6). This demonstrates thebenefit of continued development of pipeline analysis software. The fraction ofall host stars with multiple candidates has grown from 17% to 20%, and thepaucity of short-period giant planets in multiple systems is still evident. Theprogression toward smaller planets at longer orbital periods with each newcatalog release suggests that Earth-size planets in the Habitable Zone areforthcoming if, indeed, such planets are abundant.

Planetary Candidates Observed by Kepler, III: Analysis of the First 16 Months of Data