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Combining PET with MRI in a single system provides clinicians with complementary molecular and anatomical information. However, existing integrated PET/MRI systems do not have time-of-flight (ToF) PET capabilities. This work describes an MRI-compatible front-end electronic system with ToF capabilities. The approach employs a fast arrival-time pickoff comparator to digitize the timing information, and a laser diode to drive a 10 m fiber-optic cable to optically transmit asynchronous timing information to a photodiode receiver readout system. The FWHM jitter of the comparator and this electo-optical link is 11.5 ps in response to a fast digital pulse. When configured with LYSO scintillation crystals and Hamamatsu MPPC silicon photo-multipliers the comparator and electro-optical link achieved a 511 keV coincidence time resolution of 254.7 ps +/- 8.0 ps FWHM with 3 × 3 × 20 mm(3) crystals and 166.5 +/- 2.5 ps FWHM with 3 × 3 × 5 mm(3) crystals.

Readout strategy of an electro-optical coupled PET detector for time-of-flight PET/MRI