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Fluorescent nuclear track detectors (FNTDs) based on Al2O3:C,Mg singlecrystal combined with confocal microscopy provide 3D information on ion trackswith a resolution only limited by light diffraction. FNTDs are also idealsubstrates to be coated with cells to engineer cell-fluorescent ion trackhybrid detectors. This radiobiological tool enables a novel platform linkingcell responses to physical dose deposition on a sub-cellular level in protonand heavy ion therapies. To achieve spatial correlation between single ion hitsin the cell coating and its biological response the ion traversals have to bereconstructed in 3D using the depth information gained by the FNTD read-out.FNTDs were coated with a confluent human lung adenocarcinoma epithelial celllayer. Carbon ion irradiation of the hybrid detector was performedperpendicular and angular to the detector surface. In-situ imaging of thefluorescently labeled cell layer and the FNTD was performed in a sequentialread-out. Making use of the trajectory information provided by the FNTD theaccuracy of 3D track reconstruction of single particles traversing the hybriddetector was studied. The accuracy is strongly influenced by the irradiationangle and therefore by complexity of the FNTD signal. Perpendicular irradiationresults in highest accuracy with error of smaller than 0.10{\deg}. The abilityof FNTD technology to provide accurate 3D ion track reconstruction makes it apowerful tool for radiobiological investigations in clinical ion beams, eitherbeing used as a substrate to be coated with living tissue or being implanted invivo.

Ion track reconstruction in 3D using alumina-based fluorescent nuclear track detectors