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Radio continuum, Spitzer infrared, optical and XMM-Newton X-ray and UVM2observations are used to study large-scale shock fronts, young star complexes,and the galactic nuclei in the interacting galaxies NGC 2207/IC 2163. There aretwo types of large-scale shock fronts in this galaxy pair. The shock frontalong the rim of the ocular oval in IC 2163 has produced vigorous starformation in a dusty environment. In the outer part of the companion side ofNGC 2207, a large-scale front attributed to disk or halo scraping isparticularly bright in the radio continuum but not in any tracers of recentstar formation or in X-rays. This radio continuum front may be mainly in thehalo on the back side of NGC 2207 between the two galaxies. Values of the fluxdensity ratio S(8 um)/S(6 cm) of kpc-sized, Spitzer IRAC star-forming clumps inNGC 2207/IC 2163 are compared with those of giant H II regions in M81. We findevidence that in 2001 a radio supernova was present in the core of feature i, amini-starburst on an outer arm of NGC 2207. X-ray emission is detected from theNGC 2207 nucleus and from nine discrete sources, one of which corresponds to SN1999ec, and another may be a radio supernova or a background quasar. The X-rayluminosity and X-ray spectrum of the NGC 2207 nucleus suggests it is a highlyabsorbed, low luminosity AGN.

NGC 2207/IC 2163: A Grazing Encounter with Large Scale Shocks