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The recent resurgence of invasive group A streptococcal disease has been paralleled by the emergence of the M1T1 clone. Recently, invasive disease initiation has been linked to mutations in the covR/S 2-component regulator. We investigated whether a fitness cost is associated with the covS mutation that counterbalances hypervirulence.

Genetic Switch to Hypervirulence Reduces Colonization Phenotypes of the Globally Disseminated Group AStreptococcusM1T1 Clone