Open AccessMultiple Genetic Backgrounds of the AmplifiedPlasmodium falciparumMultidrug Resistance (pfmdr1) Gene and Selective Sweep of 184F Mutation in Cambodia
Author(s) -
Sumiti Vinayak,
Tauqeer Alam,
Rithy Sem,
Naman K. Shah,
Agustina Susanti,
Pharath Lim,
Sinuon Muth,
Jason D. Maguire,
William O. Rogers,
Thierry Fandeur,
John W. Barnwell,
Ananías A. Escalante,
Chansuda Wongsrichanalai,
Frederick Ariey,
Steven R. Meshnick,
Venkatachalam Udhayakumar
Publication year - 2010
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/651949
Subject(s) - biology , genetics , plasmodium falciparum , linkage disequilibrium , allele , population , haplotype , mutation rate , mutation , gene , malaria , demography , sociology , immunology
The emergence of artesunate-mefloquine (AS+MQ)-resistant Plasmodium falciparum in the Thailand-Cambodia region is a major concern for malaria control. Studies indicate that copy number increase and key alleles in the pfmdr1 gene are associated with AS+MQ resistance. In the present study, we investigated evidence for a selective sweep around pfmdr1 because of the spread of adaptive mutation and/or multiple copies of this gene in the P. falciparum population in Cambodia.