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The emergence of artesunate-mefloquine (AS+MQ)-resistant Plasmodium falciparum in the Thailand-Cambodia region is a major concern for malaria control. Studies indicate that copy number increase and key alleles in the pfmdr1 gene are associated with AS+MQ resistance. In the present study, we investigated evidence for a selective sweep around pfmdr1 because of the spread of adaptive mutation and/or multiple copies of this gene in the P. falciparum population in Cambodia.

the journal of infectious diseases

Multiple Genetic Backgrounds of the Amplified<i>Plasmodium falciparum</i>Multidrug Resistance (<i>pfmdr</i>1) Gene and Selective Sweep of 184F Mutation in Cambodia

Multiple Genetic Backgrounds of the AmplifiedPlasmodium falciparumMultidrug Resistance (pfmdr1) Gene and Selective Sweep of 184F Mutation in Cambodia