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Schistosoma japonicum is the most pathogenic agent of hepatosplenic schistosomiasis. It causes fibrosis of the central (CentF) and peripheral (PerF) portal areas. We investigated whether CentF and PerF in Chinese fishermen infected with S. japonicum were associated with an abnormal production of cytokines and chemokines that, in experimental models, have been implicated in the regulation of fibrosis.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Regulatory Role of Interleukin–10 and Interferon-γ in Severe Hepatic Central and Peripheral Fibrosis in Humans Infected with<i>Schistosoma japonicum</i>

Regulatory Role of Interleukin–10 and Interferon-γ in Severe Hepatic Central and Peripheral Fibrosis in Humans Infected withSchistosoma japonicum