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Anion conductance and permeability sequences were obtained for frog skeletal muscle membranes from the changes in characteristic resistance and transmembrane potential after the replacement of one anion by another in the bathing solution. Permeability and conductance sequences are the same. The conductance sequence at pH = 7.4 is Cl(-) Br(-) &gt; NO(3) (-) &gt; I(-) &gt; trichloroacetate &gt;/= benzoate &gt; valerate &gt; butyrate &gt; proprionate &gt; formate &gt; acetate &gt;/= lactate &gt; benzenesulfonate &gt;/= isethionate &gt; methylsulfonate &gt; glutamate &gt;/= cysteate. The anions are divided into two classes: (a) Chloride-like anions (Cl(-) through trichloroacetate) have membrane conductances that decrease as pH decreases. The last six members of the complete sequence are also chloride like. (b) Benzoate-like anions (benzoate through acetate) have conductances that increase as pH decreases. At pH = 6.7 zinc ions block Cl(-) and benzoate conductances with inhibitory dissociation constants of 0.12 and 0.16 mM, respectively. Chloride-like and benzoate-like anions probably use the same channels. The minimum size of the channel aperture is estimated as 5.5 x 6.5 A from the dimensions of the largest permeating anions. A simple model of the channel qualitatively explains chloride-like and benzoate-like conductance sequences and their dependence on pH.

Anion Conductance of Frog Muscle Membranes: One Channel, Two Kinds of pH Dependence