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I t seemed probable, from previous experimentation, that in salamanders the thyroid attains the highest degree of its activity during the time of metamorphosis. Since the decrease in the size and weight of the animal, the considerable destruction of tissues, and the exophthalmus are the most outstanding symptoms during metamorphosis, it was suggested that at this time the thyroid functions in a n excessive manner. If this assumption is correct, the unusual condition of the thyroid during metamorphosis should be expressed in the growth curve of this organ. The following observations seem to prove that the growth of the thyroid during metamorphosis is characteristic and does not correspond to the growth of the animal as a whole, or to the growth of other organs. The relative weights of the thyroid and postbranchial body were found by reconstructing the organs (exclusive of the connective tissue and blood vessels) from wax, after the method of Born, at a magnification of one hundred times. The weights of both organs, relative to the size of the ani-

THE GROWTH OF THE THYROID AND POSTBRANCHIAL BODY OF THE SALAMANDER, AMBYSTOMA OPACUM