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Animal red blood cell in vivo survival curves, obtained by the radioiron tagging of populations of approximately the same age followed by the administration of non-radioactive iron to suppress radioiron reutilization, have been subjected to mathematical analysis on the basis of the three following assumptions:- (A) Red blood cells disappear from the circulation as the result of senescence: there is an average life span around which the life spans of individual cells are distributed in the usual way. (B) Red blood cells may be removed from the circulation by a process of random destruction which continuously removes a constant fraction of the cells present at any moment irrespective of age or other characteristics. (C) Under the conditions of the experiments described, a fraction of the radioiron, constant for each animal, is reutilized in new red cell formation when released by red cell destruction. This mathematical analysis indicates the following average life spans with the respective standard errors of the mean: dog 107 days +/- 1.14; rabbit 67.6 days +/- 1.94; cat 68.4 +/- 1.50. The mathematical treatment presented has permitted a consideration of the theoretical variation of red cell life spans which was found in these experiments to be relatively small for all three species studied. In the rabbit and cat 2.5 per cent of tagged populations of red cells of the same age would theoretically have disappeared by senescence 17 days before the average life span was reached. The variation of red cell life in the dog was slightly less. Animals of the three species studied, in spite of apparently normal health, exhibited varying degrees of random destruction of both autogenous and transfused fresh normal homologous red cells. As yet, we have no explanation for this random loss of cells occurring in apparently healthy normal animals. The method of mathematical analysis presented is applicable to animal red cell survival studies employing radioiron in which differing rates of random destruction are operating in the removal of red cells.

AN ANALYTICAL STUDY OF IN VIVO SURVIVAL OF LIMITED POPULATIONS OF ANIMAL RED BLOOD CELLS TAGGED WITH RADIOIRON