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The enzyme d-ribonuclease is antigenic. Antisera, prepared by three different methods, reacted against antigen dilutions up to one million. Apparently the homologous antiserum, when combined with the d-ribonuclease inhibited the activity of the enzyme from 10 to 30 per cent.

THE ANTIGENICITY OF d-RIBONUCLEASE; THE INHIBITION OF THE ENZYME BY ITS HOMOLOGOUS IMMUNE SERUM