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An investigation of the immunogenicity of vaccines prepared from closely related virulent and avirulent strains of S. typhosa is reported. No evidence was obtained of any essential relationship between the virulence of the strains employed and their immunogenicity, as determined by active-immunity mouse-protection tests and by the agglutinin and mouse-protective antibody response in human beings.

THE VIRULENCE AND IMMUNOGENICITY OF STRAINS DERIVED FROM SALMONELLA TYPHOSA 58 (PANAMA CARRIER)