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There has been described recently from this laboratory 2 an independent affection of the liver characterized anatomically by "multiple, irregular, circumscribed solution of liver cells without parenchymatous degeneration or coagulation necrosis, and associated with a corresponding lobular blood and bile stasis in the affected areas. It appeared that the protoplasm and later the nucleus of the cells simply wasted and dissolved, leaving a more or less well preserved reticulum with stagnant blood and bile." The condition has been observed here six times (two unpublished cases) and seems to be characterized clinically by jaundice and mental symptoms, usually delirium, followed by a rapidly fatal issue. To the lesion as a whole Oertel has applied the term "multiple non-inflammatory necrosis of the liver with jaundice." The cellular changes he designates "cytolysis." While several observers, notably Flexner in this country and Fr. Muller in Germany, correlating chemical with morphological findings, have sought to explain certain pathological processes on the basis of the property of certain cells to elaborate digestive ferments, practically no work has been done on the structural changes brought about in the tissues by the action of such substances. Hauser a in 1886 kept small pieces of liver under aseptic conditions for varying lengths of time. The specimens gradually softened.

OBSERVATIONS ON THE CYTOLOGY OF MULTIPLE NON-INFLAMMATORY NECROSIS OF THE LIVER AND ON CERTAIN RELATED DEGENERATIVE CHANGES IN CELLS