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I t is proposed to present in this communicat ion the results of experiments made with a view to influencing the virulence of tumor cells by incubation previous to inoculation. The Jensen mouse carcinoma has been employed exclusively in this series of experiments, and, in view of the extensive literature on the subject, there is no need of further description of the tumor. Jensen, 1 Loeb, Sticker, and Haaland have all, in the course of their t ransplantat ion experiments with animal tumors, determined the point at which the tumor materials, through exposure to high temperature, previous to inoculation, were rendered incapable of further proliferation. Jensen, working with his mouse carcinoma, found tha t exposure of the tumor materials suspended in normal salt solution (0.8 per cent.) to temperatures of 47 ° C. and upwards for a period of five minutes entirely destroyed the tumor cells, whilst at a temperature of 46 ° C. a distinct d imin tion in the yield of tumors, as compared with that obtained at lower temperatures, was observed. The number of animals employed in this experiment was extremely small, no control was macle at normal temperatures, and no statements were made regarding the relative speed at which individual tumors in the different series developed. Loeb ~ observed tha t exposure of the rat sarcoma, with which he was working, to temperatures of 45 ° C. and upwards for periods of thir ty minutes or more, was sufficient to prevent

ON THE INFLUENCE EXERTED ON THE VIRULENCE OF CARCINOMA IN MICE BY SUBJECTING THE TUMOR MATERIALS TO INCUBATION PREVIOUS TO INOCULATION