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The leucocytes of an inflammatory exudate contain an enzyme which even after death of the cell is capable of digesting fibrin, coagulated serum, and other proteid substances. This digestion, as Ft. Mflller 1 has shown, occurs more rapidly in a weakly alkaline medium. It is doubtless such enzymes t h a t cause intra-cellular digestion of proteid material engulfed by phagocytic leucocytes. In a preceding article 2 I have shown that cells carefully separated from the serum of an inflammatory exudate obtained by injecting aleuronat into the pleural cavity of a dog cause much more active digestion of coagulated serum in a two-tenths per cent. solution of sodium carbonate than in acetic acid diluted to the same strength. The cells of an exudate removed twenty-four hours after the injection of aleuronat are almost wholly polynuclear leucocytes with fine granulation. Since the serum of the exudate and of the blood exerts an anti-enzymotic action which in an alkaline medium inhibits the digestion of proteid, it is necessary to free the cells from serum in order to study the behavior of the ferments which they contain. To determine the source of the ferments contained in the poly-nuclear leucocytes, attention has been directed to the bone-marrow. A suspension of cells obtained by finely dividing the bone-marrow of the dog and repeatedly washing by centrifugaliza-tion with normal salt solution (o.8 5 per cent.) has been allowed to act upon serum diluted with salt solution and heated in order to destroy its anti-enzymotic action. The amount of coagulable proteid transformed by digestion into non-coagulable form has 1 Zeit. far. klin. Med., i888, xiii, I49.

THE PRESENCE IN THE BONE-MARROW OF ENZYMES RESEMBLING THOSE OF LEUCOCYTES