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One of several conclusions reached by Howell in his study of the phenomena of shock * is the following: "Inject ions of alkaline solutions of sodium carbonate, intravenously or into the rectum during shock, increase markedly the amplitude of the heart-beat and bring about a rise of arterial pressure. When the shock is moderate (aortic tension of 6o-7o ram. Hg.), the injections may restore arterial pressure to an approximately normal level. When the shock is severe (aortic tension of 20-40 ram. Hg.), the injections may increase the arterial pressure by about zoo per cent for long intervals, and the effect when it wears off may be restored by repeating the injections. The effect of the injections is due chiefly or entirely to a direct action on the heart." Having in mind the possible clinical value of injections of alkaline solutions as a means of combating the condition of shock, Professor Howell then suggested to the author to pursue this line of investigation still farther, a suggestion which resulted in the series of experiments which will now be described. The present communication deals with the cardio-vascular effects of intravenous infusion of solutions containing sodium bicarbonate after severe hmmorrhage. The animals used were dogs, and the phenomena observed were the pulse rate and the blood "pressures," viz., systolic, mean, diastolic, and pulse

THE CHANGES IN THE HEART RATE AND BLOOD "PRESSURES" RESULTING FROM SEVERE HÆMORRHAGE AND SUBSEQUENT INFUSION OF SODIUM BICARBONATE