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The positive detection of the virus of poliomyelitis in the nasal secretions of 2 children, 16 and 13 days after the onset of the disease, is described. 7 animals which had been inoculated with other concentrates became ill with symptoms and temperature elevations suggestive of poliomyelitis, from 1 to 3 weeks following inoculation, but without definite paralysis. In 2 of these animals which were sacrificed, the histologic findings were compatible with the diagnosis of poliomyelitis but were not typical. Of the serums of the 5 remaining animals 4 failed to neutralize stock virus, whereas the serum of the fifth neutralized the virus on two different occasions. This serum was obtained from a monkey that had been inoculated with concentrated nasal secretions of a child 43 days after the onset of illness. It is suggested that the present quarantine period of 3 weeks is compatible with the available data. It is further suggested that the methods of procedure described may be useful in similar investigations.

SURVIVAL OF THE VIRUS OF POLIOMYELITIS IN THE ORAL AND NASAL SECRETION OF CONVALESCENTS