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The observations reported in this paper demonstrate that the intravascular interaction of bacterial and animal protein antigens with homologous antibodies at the site of a tissue made vulnerable by bacterial filtrates induces prompt severe hemorrhagic necrosis in this tissue. In the light of these observations there is offered an explanation of the mechanism underlying focal and skin bacterial hypersensitiveness.

PHENOMENON OF LOCAL SKIN REACTIVITY TO BACTERIAL FILTRATES IN ITS RELATION TO BACTERIAL HYPERSENSITIVENESS