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In general, there is a reversal of the normal in the ratio of clasmatocytes in the spleen to clasmatocytes in the bone marrow in pernicious anemia, with a marked tendency toward the phagocytosis of young, immature, nucleated red blood cells in the bone marrow. The peripheral blood picture suggests that these cells had never been in circulation. The observations made do not indicate that the spleen takes any directly active part in an increased destruction of blood in pernicious anemia.

the journal of experimental medicine/the journal of experimental medicine

THE TYPE OF PHAGOCYTIC CELL AND ITS RELATIVE PROPORTIONS IN HUMAN BONE MARROW AND SPLEEN, AS IDENTIFIED BY THE SUPRAVITAL TECHNIQUE, WITH SPECIAL REFERENCE TO PERNICIOUS ANEMIA