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Drops of coal tar introduced into the subcutaneous tissue attract the fibroblasts, endothelial and other cells to them. These cells suffer degenerative changes through this action of the tar and the animal suffers cachectic-like changes and death from large doses of it introduced into the subcutaneous tissue. This action of the coal tar is limited to a short period of time, after which it becomes inert. The cells which have been drawn to it and which have not completely degenerated then slowly recover. Where large numbers of these cells are drawn to the tar they grow and divide after recovering from the initial effects of the tar. Cancer may develop. Where only a few cells are drawn to the tar they lay down intercellular fibrils and a scar eventually develops. Vitamin A fed in more than ample quantities to these animals protects the animals and the cells against the toxic action of the tar and stimulates and prolongs their secondary growth. Vitamin B stimulates the secondary growth of these cells. This action is limited in extent and time. It is followed by an early degeneration and hyalinization of the tissue.

THE RELATION OF THE VITAMINS TO THE REACTION INDUCED BY COAL TAR IN THE TISSUES OF ANIMALS