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Although the alterations in the composition of the blood which follow uncomplicated experimental double nephrectomy are of much interest in relation to the pathology of hlunan ureemic states, the literature relating to the subject is exceedingly limited, and it is certain that investigators have not given it the attention of which it is worthy. I t is the aim of this paper to present concisely the results of experimental work relating chiefly to the chemical changes that occur in the blood as the result of double nephrectemy. In most instances dogs were employed as the subjects of these observations, and both kidneys were removed at one operation. The chief symptoms following the removal of both kidneys in dogs are as follows: lowering of the temperature, loss of appetite, drowsiness, vomiting, diarrhea. In a few instances the second kidney was removed several days after the removal 9f the first. In a smaller series of cases studies were made of the blood after both ureters had been tied just below the pelves of the kidneys. In almost all cases the animals were carefully watched, and were bled to death as soon as there were indications tha* life was not likely to be prolonged for many hours. This method of procedure is of importance, because there is reason to think that the composition of the blood undergoes alterations in certain respects by contact post mortem with the tissues.* Thus v. Limbeck obtained the follo~ving results:

ON ALTERATIONS IN THE COMPOSITION OF THE BLOOD RESULTING FROM EXPERIMENTAL DOUBLE NEPHRECTOMY