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I t has long been recognized that tuberculous infection of long bones originates and is in great part confined to the metaphysls and epiphysis. There is a marked contrast in this localization to the diffuse process which follows infection with pyogenic organisms, and it is not surprising that many conjectures have been made to explain the observed facts. Notable among these is the suggestion of Lexer, 1 whose anatomical studies led him to believe that embolic deposit of bacteria in the region of the metaphysis is favored by the course of the arteries. On the other hand, Ely' claims that peculiarities in the structure of the bone marrow more clearly explain the facts. The following experiments were done to examine the latter factor. Nor ~ttempt was made to infect the bone in a manner analogous to spontaneous infection in man, as our interest is concerned with the cellular reaction which follows the infection, rather than with the path of the infection. As an aid in the determination of the various cell types the animals were vitally stained. In normal vitally stained animals the leucocytes and the megacaryocytes show no deposits of the dye. The fibroblasts are as a rule also free from dye, though in intensely stained animals a few fine granules are seen at either end of the nucleus. The cell that shows the vital stain in greatest amount is the reticulo-endothelial cell which lines the venous spaces of the marrow. The protoplasm of

EARLY CHANGES FOLLOWING THE INJECTION OF TUBERCLE BACILLI INTO THE METAPHYSIS OF THE LONG BONES OF ANIMALS