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Pneumococcus lipovacdne confers a definite protection against pneumococcus infection in mice. The protective quality is not destroyed, and apparently is not greatly diminished, by heating to 130 degrees C. for 3 hours or 120 degrees C. for 12 hours. Typhoid lipovaccine gives rise to the formation of agglutinins in rabbits but to a lesser degree than saline suspensions. The antigenic qualities of the typhoid lipovaccine are greatly injured by heating to 130 degrees C. for 3 hours.

THE STERILIZATION OF LIPOVACCINES