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1. The hypodermic administration of tethelin increases markedly the rate of growth of the primary tumor and the tendency to form metastases in rats inoculated with carcinoma, in this, as in other respects, reproducing the action of the whole anterior lobe of the pituitary body. 2. Other alcohol-soluble extractives of the anterior lobe of the pituitary body, with the exception of the lecithin fraction, exert no appreciable effect upon the growth of carcinomata in rats. 3. The lecithin fraction, as in previously reported experiments in which we employed lecithin obtained from eggs, causes evident retardation of the growth of carcinomata in rats.

the journal of experimental medicine/the journal of experimental medicine

THE INFLUENCE OF TETHELIN, AND OF OTHER ALCOHOL-SOLUBLE EXTRACTIVES FROM THE ANTERIOR LOBE OF THE PITUITARY BODY, UPON THE GROWTH OF CARCINOMATA IN RATS