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In a recent paper ( I ) the effect of certain foods on the production and prevention of goitre in brook trout (Salvelinus fontinalis) was described and it was shown that a continuous diet consisting only of hog's liver and heart 1 quickly (in one to two months) induces well marked thyroid hypertrophy and hyperplasia, and that when hashed fresh sea fish alone was substituted, further hyperplasia was prevented, and any existing thyroid hyperplasia involuted to its colloid or quiescent state. In the present communication will be given data concerning the rapidity of the involution following the substitution of the fish diet, and the time limits within which it is completed, and also, for comparison, the time limits of the involution induced by other means in Lake Erie pike, in brook trout, and in mammals (dogs). The fish used in these observations were taken from the regular stock hatched about January 15, I9I 3, and distributed to the ponds about July I. They had, therefore, in common with the entire I9I 3 hatch, been fed with finely divided hog's liver for the first few months (four to five), and after that with a mixture of heart muscle and liver. I arbitrarily chose fish from pond 8, 2 since complete examinations made in August of all the I9I 3 hatch, both those living in the troughs and those in the ponds, showed approximately the same degree of thyroid hyperplasia.

THE RAPIDITY OF THE INVOLUTION OF ACTIVE THYROID HYPERPLASIAS OF BROOK TROUT FOLLOWING THE USE OF FRESH SEA FISH AS A FOOD