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A tacit assumption of cancer immunology has been that tumors express non-self or "foreign" antigens. The recent identification of a handful of potentially immunogenic cancer antigens shows that they are not truly foreign. Although the boundary between self and non-self is not well-defined, this first look at cancer antigens fits more with a self/altered self paradigm than with the non-self paradigm for antigens recognized in infectious diseases.

Cancer antigens: immune recognition of self and altered self.