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The literature on the .subject of ,the curative agents for trypanosomiasis indicates that the arsenic derivatives available at present, while possessing some value in .treating small laboratory animals experimentally inoculated, are of little or no value in treating the large animals naturally subject to the disease. Holmes I and others have cured cases .of surra by means of arsenic or some of its derivatives. But with H,olmes's method I have failed completely in murrina, the trypanosomal disease of horses .of Panama, for, whenever it was possible by careful dosage ,to destroy the trypanosomes, the horses or mules always died soon afterwards of arsenic poisoning. Practically all the successful chemotherapeu,tical applications ,of arsenic and its derivatives in the treatment of trypanosomiasis have been made with small laboratory animals. Trypanos,omiasis apparently occupies a positi.on between malaria and syphilis with regard ,to the amount of actively acquired immunity derived from infeet~o.n. In malaria repeated and continued a,ttacks result in a definite, though not high grade, immunity. Why may not immunity be derived in trypanos.omiasis as well, by the producti.on of a low grade infection with an avirulent strain ? The experiments to be described were carried out with a view of showing that immunization of large animals can be effected by means of an avirulent strain of a pathogenic trypanos'ome

THE IMMUNIZATION OF LARGE ANIMALS TO A PATHOGENIC TRYPANOSOME (TRYPANOSOMA HIPPICUM (DARLING)) BY MEANS OF AN AVIRULENT STRAIN