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Although well-known for many years, the inherent toxic action of certain normal blood sera when injected into animals of different species, has recently attracted renewed attention owing to the many points of similarity in the symptoms of animals dying of such injections and of those dying of anaphylactic shock. The older studies Of phenomena belonging in this category followed closely in the footsteps of experiments on transfusion, and as early as 1666 a commission of the London Royal Philosophical Society reported deaths following transfusion, alleging intravascular coagulation as the probable cause of death. The cause of death following injections of foreign whole blood, blood cells, and serum has, since that time, occupied the attention of many workers whose studies need not be reviewed for the purposes of this paper. Chief among them were Magnani, Brown-Sequard, Magendie, and, more recently, Naunyn, Landois, and Ponfick. 1

ON THE TOXIC ACTION OF CERTAIN NORMAL SERA AND ITS RELATION TO ANAPHYLAXIS