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Ribbert (I) considers the stroma of paramount importance in the genesis of cancer. He believes that every normal tissue cell possesses an inherent power for unlimited proliferation, and may change into a cancer cell. The only condition for this transformation is a preliminary change in the surrounding connective tissue, which impairs the normal association of the cell with the rest of the organism. Bonney (2), in a recent investigation on the connective tissue in carcinoma, reaches very similar conclusions, i. e., that the formation of carcinoma is always preceded by a precarcinomatous state, which consists in various inflammatory processes in the surrounding tissues. This precarcinomatous process assists the progress of the growth of the tumor. According to these investigators, the changes in the connective tissue are the primary etiological factors in the formation of cancers. ttansemann (3), Heidemann (4), Borst (5), and many other pathologists, on the other hand, deny the great importance of the connective tissue for the formation of cancer. According to the view of these writers, the main functional part in cancer is the parenchyma, and the stroma is only formed subsequently under the influence of the cancer cells. This opinion is based on the following grounds : The beginning of a new growth is not always accompanied by changes in the surrounding connective tissue. Furthermore, many characteristics in the morphological appearance of malignant tumors indicate that the connective tissue

THE RELATION OF THE REACTIVE STROMA FORMATION TO THE TRANSPLANTABILITY OF THE CANCERS OF THE WHITE RAT