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Through the graded action of physical and chemical agencies upon the tumor material before inoculation, it is possible experimentally to decrease the energy of tumor growth, as was shown by Leo Loeb in his investigations in serial transplantations of thyroid sarcomas of rats. 1 In a detailed investigation, a report of which will appear elsewhere, E. P. Corson White and Leo Loeb have studied the decrease in growth-energy produced by similar agencies in the carcinoma of white mice. It was of interest to investigate how far the morphological changes in such tumors corresponded to the experimentally produced variations in the energy of growth. During the past year, therefore, a systematic microscopic study has been made of the different generations of a carcinoma transplanted into white mice. The original tumor had developed spontaneously in a mouse which Dr. Loeb obtained from Granby, Mass. The sections studied covered a period of experimentation with the tumor extending from March, 19o7, to June, 191o, and comprised all generations produced within that time. The sections were divided into four groups according to the history of the tumor. (a) Sections of the original tumor transplanted without experimental interference or modification, " the unheated series."

the journal of experimental medicine/the journal of experimental medicine

MORPHOLOGICAL CHANGES OBSERVED IN A MOUSE CARCINOMA IN THE COURSE OF LONG-CONTINUED TRANSPLANTATION, AND THE INFLUENCE OF AN EXPERIMENTALLY PRODUCED DECREASE IN THE GROWTH-ENERGY OF THE TUMORS UPON THEIR MORPHOLOGICAL CHARACTER