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The ability of parental to F(1) spleen grafts to regenerate was equal to that of parental to parental or to F(1) or F(1) spleen grafts. Cytotoxicity analysis of parental to F(1) spleen and thymic grafts indicated that these "regenerated grafts" were composed of F(1) lymphocytes. Regenerated parental to F(1) spleen grafts were incapable of producing runt disease in newborn F(1) animals.

THE REGENERATION OF F1 HOST CELL SPLEEN AND THYMUS AT ECTOPIC SITES IN F1 ANIMALS INDUCED BY IMPLANTATION OF PARENTAL SPLEEN AND THYMUS