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There is hardly any doubt left in the minds of pathologists that the transplantable tumors in the white rats and mice, recently discovered by Hanau ( I ) , L. Loeb (2) , Jensen (3)and others, resemble clinically very closely human carcinoma and sarcoma. These tumors grow to large size, occasionally weighing as much as the animal on which they grow; they are malignant to the animal, and frequently fatal to the host. There were noticed local recurrences after extirpation of the original tumor and metastases, usually in the lungs. The main feature distinguishing the tumors of white rats and mice from human cancer as well as from tumors of most other animals, lies in the fact that the latter cannot be transplanted into another individual of the same species, while in the former this can be accomplished not infrequently. The transplantability of these tumors may be due to the great inherent power of proliferation of the tumor cells. This inherent proliferating capacity would then be, not only much greater than in any normal cell, but also greater than the proliferating power of a cancer cell of any other animal species. This power would not depend on the character of the tissues to which the cell is transplanted. On the other hand, it is possible that the cancer cell in a white rat or mouse is not different from a cancer cell in any other animal species, but the organisms of the former animals may react differently to tumor transplantations.

THE REACTIVE CELL PROLIFERATION IN THE WHITE RAT; AND ITS RELATION TO THE GENESIS OF TRANSPLANTABLE TUMORS