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BY reasons which will be discussed in a later part of this paper and because it seemed that the action of such a substance would be of interest in connection with the study of contracture, I have been led to investigate the effect of ether on the form of contraction in response to a single stimulus of muscles which have been exposed to the influence of veratrine, of 0.6-per-cent sodium-chloride solution, and of dehydration. The effect of all these is to change the simple twitch of a normal muscle into a contraction enormously increased in amount and duration. Is the altered condition of the muscle, of which this abnormal form of response to a single stimulus is the outward and visible sign, stable as long as contractility persists under etherization, or is there associated with the gradual loss of contractility a change in the form of its expression--a return to the normal twitch of short duration ?

OF THE ACTION OF ETHER ON CONTRACTURE AND OF POSITIVE KATHODIC POLARIZATION OF VERTEBRATE VOLUNTARY MUSCLE