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T~E lesions which are produced in the kidneys by the staphylococcus pyogenes aureus have been carefully studied. Experiments made by injecting pure cultures of the organism into susceptible animals go to show that the resulting lesions are of the same general character as those observed in man. In the human kidney they appear as smaller or larger abscesses and loci of necrosis which have the form of infarctions. The number, situation, and size of the abscesses differ in different cases. They may be homogeneously distributed through both cortex and pyramids, and are often arranged in rows, a single abscess in depth, of which the general direction is parallel to that of the tubules. In the case of these single abscesses, especially those which appear in the pyramids, the length almost always greatly exceeds the breadth, their long diameter being at right angles to the surface of the kidney, and following the course of the collecting tubules. The effects produced in the kidneys of rabbits by the injection of virulent cultures of this organism into the ear vein differ, however, in some respects from those seen in man. The lesions appear in the form of small white, rather firm foci, which are usually more numerous in the pyramids than in the cortex. On microscopical examination of such a focus, a mass of organisms is found in the centre. Around this there is an area of complete necrosis, in which the tubules filled with granular material can be recognised, and external to this again is seen an area of purulent infiltration.

A STUDY OF THE CHARGES PRODUCED IN THE KIDNEYS BY THE TOXINS OF THE STAPHYLOCOCCUS PYOGENES AUREUS