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The recognition of calcium as a general requirement for secretory activity in diverse cells storing their products in membrane-limited granules led to the concept of stimulus-secretion coupling involving operation of a common secretory mechanism, calcium-activated exocytosis (6 ; see also 7, 8) . On this hypothesis, physiological stimuli evoking various secretions act by promoting the appearance of an excess of free calcium ions someplace in the cell, either by increasing the permeability of the plasma membrane to allow entry of extracellular calcium or by mobilizing cellular calcium, and the rise in the calcium ion concentration at some critical site then induces exocytosis . The present experiments were designed to assess, by electron microscopy, some recent observations on mast cells which appear to offer fresh support for this scheme and suggest new approaches . Mast cells, long known to require calcium for anaphylactic release of histamine (15), were amongst the first suspected of utilizing the calcium-activated exocytosis mechanism (6, 9) . Such

ELECTRON MICROSCOPE EVIDENCE OF CALCIUM-INDUCED EXOCYTOSIS IN MAST CELLS TREATED WITH 48/80 OR THE IONOPHORES A-23187 AND X-537A