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Differentiat ion of several cell types is inhibi ted by 5-bromodeoxyuridine (BUdR) (1-3, 9, 12). Since B U d R can be incorpora ted into D NA in place of thymidine (TdR) (12), the inhibi t ion of different ia t ion may be due to the presence of B U d R in the DNA of the cell. In Acanthamoeba castellanii, DNA synthesis cont inues t h rough overt different iat ion of the t rophozoite into the d o r m a n t cyst. 1 Since cell division is t e rmina ted before encystment is induced, cont inua t ion of D N A synthesis suggested t ha t the DNA synthesized at this t ime migh t be impor t an t for normal differentiation. Consequently, we under took experiments to de termine whe ther B U d R would interfere wi th different iat ion of A. castellanii. The present repor t deals with prel iminary observations on the effects of B U d R on growth, encystment , and excystment.

EFFECT OF 5-BROMODEOXYURIDINE ON GROWTH, ENCYSTMENT, AND EXCYSTMENT OF ACANTHAMOEBA CASTELLANII