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The adminis t ra t ion of phenoba rb i t a l to mammal s increases the metabol i sm of xenobiot ic compounds by increasing the levels of RNA, phospholipid, protein, and compounds of the microsomal elect ron t ranspor t chain (5, 14, 15, 20). These biochemical changes are viewed ul t ras t ructural ly by a proliferat ion of smooth endoplasmic rcticu lum (SER) in hepat ic pa r enchym a l cells (15). M a m m a l i a n liver has been used for most biochemical and u l t ras t ruc tura l work with phenobarb i ta l and o ther enzyme inducers. I t was not shown unt i l the last decade tha t microsomal detoxifying enzymes were present in insects (24), and only recent ly has it been shown tha t these enzymes are inducible in insects ( l , 19, 25, 27, 29, 30). Perry et al. (18) have shown tha t phenobarb i ta l increases levels of cytochrome P-450 and microsomal oxidase activity in susceptible and resistant houseflies, Musca domestica. Biochemical da ta on enzyme induct ion in insects are accumula t ing rapidly, bu t little complemen t a r y u l t ras t ruc tura l work has been done. The insect fat body often has been compared to the m a m m a l i a n liver in its metabol ic functions (8). T he present results were ob ta ined from examina t ion of oenocytes, cells located in the housefly fat body, after exposure of houseflies to phenobarb i t a l and thioacetamide.

PHENOBARBITAL-INDUCED, MEMBRANE-LIKE SCROLLS IN THE OENOCYTES OF MUSCA DOMESTICA LINNAEUS