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Protein transport directed across the luminal membrane has been studied by histologic techniques in the rat proximal tubule (9, 10) . Protein movement in the opposite direction, that is, from capillary across basement, basal and/or lateral cell membranes, and into the epithelial cell has been studied in gut (7) and in isolated renal collecting tubules (5) where separate access to luminal (mucosal) and basal (serosal) compartments is possible . Localization of transepithelial transport paths of protein molecules may provide information regarding relative permeability characteristics of individual membranes which comprise the proximal tubular epithelial membrane barrier. This study demonstrates rapid penetration of a protein molecule,

BIDIRECTIONAL TRANSPORT OF HORSERADISH PEROXIDASE IN PROXIMAL TUBULE OF NECTURUS KIDNEY