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A previous ultrastructural study of the mechanism ofglucagon secretion from the alpha cells of rabbit islets of Langerhans has suggested that the agranules disintegrate, forming small secretory particles which migrate through the cytoplasm and pass through the plasma membrane into the extracellular space (Munger, 1962) . More recently Gomez-Acebo et al . (1968) have shown that an emiocytic process (exocytosis), similar to that observed in pancreatic beta cells (Lacy, 1961), might be the mechanism of glucagon secretion from rabbit islets . In their experiments the migration of intact secretory granules to the cell surface with fusion of the granule and plasma membranes and release of the glucagon content of the granules was observed after incubation of pancreas slices in vitro in the presence of low concentrations of glucose . Rates of glucagon secretion might be expected to be stimulated under those conditions (Unger et al., 1962) . This report presents the results of a study of neural influences on the regulation of glucagon secretion from the alpha cells of cat islets . Ultrastructural examination was restricted to innervated islets from pancreas shown by immunoassay to be secreting glucagon at greater than basal rates, and it was thus possible to correlate the morphological findings with the findings of increased secretory activity .

ULTRASTRUCTURE OF THE A-CELLS OF CAT ISLETS OF LANGERHANS FOLLOWING SYMPATHETIC STIMULATION OF GLUCAGON SECRETION