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Of the various theories that have been advanced to account for the mechanism of furrow formation and cytokinesis in animal cells (9, 21), the notion of active constriction in the equatorial cortex has recently received support from physical measurements such as those reported by Wolpert (22) and Rappaport (13) . A probable structural manifestation of the "contractile ring" has been found through ultrastructural studies of cleaving invertebrate eggs, in which equatorially oriented filaments in the cleavage furrow suggest a region specialized for contraction (3, 7, 15, 17, 18) . These bundles of presumably contractile filaments have not been described in dividing cells of vertebrates or in dividing tissue cells of any organism . The present study reports the presence of a well organized filamentous component in the division furrows of mouse mammary epithelial cells .

FILAMENTS IN THE DIVISION FURROW OF MOUSE MAMMARY CELLS